... Coffee intake, glucose … The babies are also at risk of being too small during the time of pregnancy. Approximately 10% of the population is found to be rapid caffeine metabolizers, showing a high tolerance to caffeine. April 2006; ... (CYP1A2 * 1F)i nt h e CYP1A2 gene de-creases enzyme inducibility as mea-sured by the ratio of plasma or urinary. Studies have shown that taking caffeine before exercise improves performance. It is thus interesting to analyze the effect of the variants of the CYP1A2 gene on an individual, based on their caffeine intake. Cortisol is a stress-related hormone and plays a role in protecting the body from stress, as well as reducing inflammation. Excess caffeine is stored in the liver, which exits through urine. Muscle twitching is often a visible symptom of excess caffeine consumption. Over 95% of caffeine is metabolized by the CYP1A2 enzyme, which is encoded by the CYP1A2gene, and is involved in the demethylation of caffeine into the primary metabolites paraxanthine, theophylline, and theobromine (21). After all, it would be good to know if you are prone to guzzling down a little too much, especially when your caffeine sensitivity scale is tipped at the wrong end. The effect of caffeine on various systems of the body are as follows: Caffeine is a stimulant and causes mental alertness once it reaches the brain. But for people who were still smoking, the same gene expressed an association with increased blood pressure. A little caffeine during pregnancy appears to be safe in most cases. Gradually reduce the consumption of caffeine. When consumed in excess quantities, caffeine can lead to irregular heartbeat and breathing. The enzyme responsible for metabolism of caffeine is coded for by the gene CYP1A2. CYP1A2 Gene Detail. The large variability of CYP1A2 activity influences the clearance of caffeine and may be affected by factors such as gender, race, genetic polymorphisms, disease, and exposure to inducers 16,17,19. The liver enzymes responsible for metabolising caffeine are called cytochrome P450 enzymes. Approximately 10% of the population is found to be rapid caffeine metabolizers, showing a high tolerance to caffeine. Learn how your genes influence caffeine metabolism and more. This study investigated the effects of regular coffee intake on markers of glucose and lipid metabolism in coffee-naïve individuals, with novel analysis by rs762551 genotype. Metabolism of caffeine by the CYP1A2 enzyme shows substantial variation between people, 41, 42 because of both genetic and environmental factors. The enzyme CYP1A2 is responsible for metabolizing caffeine in the body and determines whether the individual is a slow or a fast caffeine metabolizer. Incorporate physical activity into your routine. The human CYP1A2 gene is located on chromosome 15 and contains seven exons. Smokers exhibit increased activity of this enzyme. However, rs762551(A) ... [PMID 22648710] CYP1A2 and coffee intake and the modifying effect of sex, age, and … This was also observed in a study conducted on 415 Japanese women. Variations in this gene broadly divide people into two groups of metabolizers: In particular, two Single Nucleotide Polymorphisms (SNP) are found to influence caffeine metabolism: The haplotype CYP1A2*1F is associated with this variation. A lot of studies vouch for caffeine boosting the RMR. Background: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption. This enzyme is also essential for removing toxic chemicals from our body and processing hormones and other products of metabolism. Analyze your CYP1A2 gene variants for Caffeine Metabolism, Find out if you carry the Slow or the Rapid variant of CYP1A2 gene, https://jamanetwork.com/journals/jama/fullarticle/202502, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474926/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735605/, https://www.researchgate.net/publication/223974368_Caffeine_intake_and_CYP1A2_variants_associated_with_high_caffeine_intake_protect_non-smokers_from_hypertension, https://www.nature.com/articles/pr201770#:~:text=Maternal%20caffeine%20intake%20may%20increase,8%2C%209%2C%2010), Morning Person or a Night Owl: How Genes Influence Your Circadian Rhythm, How Genes Influence Caffeine-induced Insomnia, How Genes Influence The Risk Of Obstructive Sleep Apnea, How Genes Influence Excessive Daytime Sleepiness. The CYP1A2 gene breaks down caffeine, several major prescription drugs, and interacts with smoking. Caffeine is a stimulant and the most commonly used drug on the planet. Caffeine is predominantly metabolized by the cytochrome p450 enzyme encoded by the CYP1A2 gene, which is then further processed by the enzymes CYP2A6 and NAT2. The C allele is considered the wild-type, even though it is the rarer allele in most populations. More infoOkay! However, those individuals who have two copies of the slow variant are slow metabolizers of caffeine and are said to be poorly tolerant of it. Our Gene Nutrition Report analyses caffeine sensitivity and metabolism, gluten sensitivity, lactose intolerance, vitamin needs, and 33 more such categories. Your caffeine levels peak about 1-hour after consumption and then start to decrease gradually. What is CYP1A2, aka the caffeine gene? The gene also plays a role in regulating an infant’s weight during the pregnancy of a woman,  and this has a link with caffeine intake. Some people are genetically predisposed to produce very little of CYP1A2 enzyme while others may generate a sufficient amount. ... approximately two cups of … This section of Caffeine Basics explains the connection between coffee or caffeine, your genes, and heart … In non-smokers, CYP1A2 variants (having either a CC, AC, or AA genotype) were associated with hypertension. One variant of the CYP1A2 gene (T allele of the SNP rs2472297) is consistently linked to a higher coffee intake than those with the more common C allele. Nutrition, Fitness, Health, Allergy, Skin, Nutrition, Fitness, Health, Allergy, Skin, Precision Medicine, MTHFR, Nutrition, Fitness, Health, Allergy, Skin, Precision Medicine, MTHFR, Carrier Status, and Traits & Personality, © Copyright 2010-20 - Xcode Life - All Rights Reserved. Caffeine tolerance in an individual is gene deep. CC, AC = CYP1A2*1C = Slow Metabolizer. The consequence of being a “rapid” or a “slow” metabolizer of caffeine can have effects on an individual’s cardiovascular health. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. During such times, the following remedies can help flush out caffeine from the system: If nothing else works, just wait! Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. If your body is dependent on caffeine, eliminating caffeine from your diet may cause symptoms of withdrawal. CYP1A2 is the key liver enzyme (special proteins that breakdown and use other substances) responsible for metabolizing caffeine. Gene breaks down caffeine, eliminating caffeine from the system: If nothing else works, just wait regulates! Liver, which is metabolized by the polymorphic cytochrome P450 enzymes to cardiovascular disease risk contains! 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