It is widely used in folk medicine, particularly in South and Southeast Asia. V. negundois a small tree about 2-8 m in height with quadrangular branches. It is a feeling that is triggered in nervous system. The conventional method for propagation of V. negundo is through seeds or root suckers. Abstract Advanced search can include the following: Vitex negundo and its medicinal value. Several investigations have probed the aberrant expression of PDCD4 with the progression of metabolic diseases, such as polycystic ovary syndrome (PCOS), obesity, diabetes, and atherosclerosis. Vitex negundo (or nirgundi or nochi) is one of the herbs mentioned in the Ayurveda and it grows in the waste lands or commonly cultivated as a hedge plant. Phytochemical and Pharmacological Profile of Vitex negundo. Apoptosis; Cancer; Reactive oxygen species; Signaling; Vitex negundo. This site needs JavaScript to work properly. Fitoterapia. Vitex negundo 161800 ± 36 143400 ± 23 5330 ± 16 200 ± 9 280 ± 10 120 ± 5 Potassium was higher in both plants but contained Adhatoda vasica 31190 ± 20.3 68070 ± 35 705 ± 8 64 ± 5 67 ± 6 41 ± 3 less Na. Several bioactive compounds obtained from VN have been commercialized and others are under investigation. Previous work on this plant reveals the presence of a variety of compounds from the leaves [1-11]. Life Cycle: Perennial Woody Recommended Propagation Strategy: Seed Country Or Region Of Origin: Asia, Africa Wildlife Value: Attracts butterflies. PMID: 32469224 [PubMed - as supplied by publisher], https://www.ncbi.nlm.nih.gov/pubmed/30311123?dopt=Abstract. Vitex Negundo is a medicinal herb. Epub 2015 Jan 30. Early ovarian ageing: is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases? Vitex negundoLinn.is credited with innumerable medicinal activities like analgesic, anti-inflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc. Also, there are ten types of EphAs (EphA1-10) and six types of EphBs (EphB1-6). Clarification of their roles in the female reproductive system is crucial to understanding the physiology and pathology of this syste... Adu-Gyamfi EA, Czika A, Liu TH, Gorleku PN, Fondjo LA, Djankpa FT, Ding YB, Wang YX. After having analyzed the various chemical components available in different parts of Vitex negundo, it is essential that focus shifts to the medicinal applica- Front Pharmacol. Vitex negundo, a medicinal plant of the family ‘Verbenaceae’ and commonly known as chaste tree or five-leaved chaste tree or horseshoe vitex. Secondly, The CCK-8 and apoptosis experiment results suggested that downregulated miR-... Vitamin D3 action within the ovary - an updated review. Tuesday, 12 January 2010. Ephrins are ligands of Eph receptors (Ephs); both of which are sorted into two classes, A and B. -, Chem Pharm Bull (Tokyo). VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. Universal Journal of Pharmacy, 2, 42-46. It is especially useful in rheumatism, rheumatic swellings of the joints and in sprains. 2015 Jan 5;225:32-9 Crossref This plant has been used for hundred of years in India and in the Philippines, where the health department endorsed its use as an herbal medicine.. Vitex negundo can be used to repel house flies. Keywords: Mol Biol Rep. 2019 Jun;46(3):3545-3555. doi: 10.1007/s11033-019-04743-5. Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer. Mol Biol Rep. 2018 Oct 11;: Authors: Gill BS, Mehra R, Navgeet, Kumar S Abstract Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. -. It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. Lagundi is generally used for the treatment of coughs, asthma symptoms, and other respiratory problems. -, BMC Complement Altern Med. Effect of solvent residues of Vitex negundo L. and Cassia fistula L. leaves (0.5 and 1%) was studied on egg laying and adult emergence of Callosobruchus maculatus Fab. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Binding of ephrins to the Eph receptors activates signaling cascades that regulate several biological processes such as cellular proliferation, differentiation, migration, angiogenesis and vascular remodeling. Vitex cannabifolia Siebold & Zucc. Please enable it to take advantage of the complete set of features!  |  Almost all the sections of the plant possess a massive amount of phytochemical secondary metabolites that impart an unparalleled variety of medicinal uses of the plant. 2015 May;29(5):633-47. doi: 10.1002/ptr.5303. AbstractAnti-M üllerian Hormone (AMH) is critical for physiologic involution of the Mullerian ducts during sexual differentiation in the male fetus. Lagundi (scientific name: Vitex negundo) is a shrub that grows in the Philippines. Pain is a feeling which may be sharp or dull, something that is unpleasant to mind and body. Xu JM, Hu BC, Yuan L, Wu YL, Luan SS, Yuan T, Wang D, Chen LX. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Vitex Species: negundo Family: Lamiaceae Uses (Ethnobotany): Various medicinal uses of various parts of the plant. The circRNA-miRNA axis functions in various diseases progression have been partially revealed in the past two decades. Vitex negundo and its medicinal value. 2018 May;16(3):147-152. doi: 10.1016/j.joim.2018.03.001. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The structure was established on the basis of chemical and spectral data. In women, AMH is a product of the small antral follicles in the ovaries and serves to function as an autocrine and paracrine regulator of follicular maturation. ConclusionsThis study confirms recent investigations demonstrating that conventional HKGs, such as GAPDH and beta-actin, are not suitable reference genes for specific pathological conditions, emphasizing the importance of determining the best HKGs on a case-by-case basis and according to tissue type. 2019 Sep;137:104265. doi: 10.1016/j.fitote.2019.104265. Vitex supplements typically contain extracts of the fruit and/or seed of the plant. PMID: 32595989 [PubMed], Cancers, Vol. -, Chem Biol Interact. In contrast, there is a growing body of evidence for a protective role of oral contraceptives. Trees and Herbs (with medicinal value) To treat disease and by using (Herbs)/herbal medicine. Analysis of flavonoids and iridoids in Vitex negundo by HPLC-PDA and method validation. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. ... medicinal value and mention its use in religious rites, while the Vamana Purana considers it to be a holy plant (Sensarma, 1998). Firstly, we found that miR-760 expression was decreased in PCOS tissues insulin treated GCs, KGN and SVOG cells. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression for case–control associations and polytomous logistic regression for histotype-specific associations, all adjusted for po tential confounders. Clipboard, Search History, and several other advanced features are temporarily unavailable. NCI CPTC Antibody Characterization Program, Phytomedicine. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling. VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. Zheng CJ, Li HQ, Ren SC, Xu CL, Rahman K, Qin LP, Sun YH. It has been used since ... medicinal properties have been ascribed to Vitex negundo Linn. Fitoterapia. eCollection 2020. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Play Value: 2013 Dec 04;13:343 Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. It is cultivated as a hedge and medicinal plant, and is also sometimes grown as an ornamental[303. The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. The phytochemical constituents of medicinal plants often function indi-vidually, additively or synergistically in improvement of health [31]. is a large aromatic shrub distributed throughout India. However, little is known about the role of the circRNA-miRNA axis in PCOS progression. This plant has been extensively investigated by many scientists for its medicinal activities. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. 4.11.3.4.1 Pentacyclic triterpenes. USA.gov. Different species of Vitex vary in chem …. Nirgundi Oil (Vitex negundo) - Benefits, Uses and Properties. It was observed that methanolic extract of Vitex negundo showed equal activity against both the bacteria with MIC value equal to 5mg/mL. COVID-19 is an emerging, rapidly evolving situation. Raji, R. (2013) Biological Activities, Chemical Constituents and Medicinal Value of Vitex negundo Linn. Abstract Mol Biol Rep. 2018 Oct 11;: Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Vitex negundo is indicated in Joint Disorder, Low Back Pain, Osteoarthritis, Rheumatoid Arthritis (Amavata), Sciatica, Spondylosis, and Vata Vyadhi. The ethanolic extract of leaves has been found safe as LD 50 dose (by oral route) of it was recorded in non-toxic dose range. is a woody plant found mainly in Indian subcontinent and its neighbouring countries. 2020 Oct 30;11:566490. doi: 10.3389/fphar.2020.566490. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Labdanes and megastigmanes from Vitex negundo var. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). Abstract HHS National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. medicinal plant for the preparation of various valuable medicines has caused drastic reduction of this important genetic resource in India. Abstract This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. It has antiseptic, astringent, anti-inflammatory and antipyretic properties. Vitex negundo and its medicinal value Author: Gill, Balraj Singh, Mehra, Richa, Navgeet,, Kumar, Sanjeev ... Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Kashyapiyakrishisukti recommends . Journal of Assisted Reproduction and Genetics. Ligands of Eph receptors ( Ephs ) ; both of which are sorted into two,. 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